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October 9, 1967JAMA258 citations

Surgery's Relevance to an Understanding of Basic Biology

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JDJ. Englebert Dunphy

Key Points

  • The aim is to explore the relationship between surgical practices and fundamental biological processes.
  • Examined the synthesis of proteins incorporating DNA and RNA interactions.
  • Discussed historical concerns related to DNA structure and replication capabilities.
  • Identified key roles of DNA and various RNAs in protein synthesis.
  • Demonstrated the potential implications of this understanding on surgical methods.

Abstract

When J. D. Watson received the Nobel Prize in medicine in 1962, a prize which he shared with Francis Crick and Maurice Wilkins, he demonstrated in his lecture at Stockholm that the synthesis of protein1required the ordered interaction of deoxyribonucleic acid and at least three types of functional ribonucleic acid. In the introduction he tells of the anxieties and concerns which he and Crick felt when they were first trying to elucidate the structure of DNA. He wrote, During the next eighteen months, until the structure became elucidated, we frequently discussed the necessity that the correct structure have a capacity for replication and, in pessimistic moods we often worried that the structure might be dull, that it would suggest absolutely nothing and excite us no more than something inert, like collagen. Watson's view of collagen is illustrative of the powerful vision of a great mind finding a new

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Cite This Study

J. Englebert Dunphy (1967) studied this question.

synapsesocial.com/papers/6a140bb37753e742da59a6e5https://doi.org/10.1001/jama.1967.03130150084015
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Microscopial Researches into the Accordance in the Structure and Growth of Animals and Plants1993 · 138 citations
  2. 2Formation of Hydroxyproline in Collagen1966 · 261 citations
  3. 3Lectures on Surgical Pathology, delivered at the Royal College of Surgeons of England1865 · 60 citations
  4. 4Evidence for the Nature of the Precursor That Is Hydroxylated during the Biosynthesis of Collagen Hydroxyproline1965 · 84 citations
  5. 5Conversion of Proline to Hydroxyproline in Collagen Synthesis1964 · 7 citations