A new retina-specific gene, X-arrestin, encoding a 388 amino acid protein with homology to other arrestins, was isolated and mapped to the proximal long arm of the X chromosome.
The study identifies and maps a novel retina-specific arrestin gene, X-arrestin, to the X chromosome.
We have been using a differential cDNA cloning approach to isolate human retina-specific and retina-enriched genes 1. A 1,314 bp cDNA was isolated by this approach, representing a highly retina-specific message encoding a 388 amino acid protein showing 58%, 50%, and 49% homology to bovine beta-arrestin, and bovine and human retinal arrestin (S-antigen), respectively. Chromosomal mapping localized this new arrestin gene to the proximal long arm of the X chromosome, hence it was named X-arrestin. In situ hybridization demonstrated its expression in the inner and outer segments and the inner plexiform regions of the retina.
Murakami et al. (Mon,) reported a other. A new retina-specific gene, X-arrestin, encoding a 388 amino acid protein with homology to other arrestins, was isolated and mapped to the proximal long arm of the X chromosome.