What question did this study set out to answer?

This study aims to evaluate how postural changes affect pulmonary diffusing capacity in COPD patients.

Alveolar–capillary reserve in COPD assessed by the pulmonary diffusing capacity response to an upright‐to‐supine postural change

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Randomized trial evaluates pulmonary diffusing capacity changes in COPD, suggesting postural assessment may aid diagnosis.

This study aims to evaluate how postural changes affect pulmonary diffusing capacity in COPD patients.
50 participants including 35 with COPD and 15 healthy controls underwent D L,CO,NO measurements in upright and supine positions.
A subset of participants completed a 12-week high-intensity interval training intervention.
Measurements assessed included D L,CO5s, V C, and others during upright-to-supine transitions.
Upright-to-supine change in D L,CO5s was significantly reduced in moderate (P < 0.001) and severe COPD (P = 0.006) compared to controls.
Pulmonary capillary blood volume response decreased in moderate (P < 0.001) and severe COPD (P = 0.021) compared to controls.
HIIT intervention did not influence pulmonary diffusing capacity metrics.

Rasmussen et al. (2026) studied this question.

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View Full Paper

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Authors

Randomized trial evaluates pulmonary diffusing capacity changes in COPD, suggesting postural assessment may aid diagnosis.

This study aims to evaluate how postural changes affect pulmonary diffusing capacity in COPD patients.
50 participants including 35 with COPD and 15 healthy controls underwent D L,CO,NO measurements in upright and supine positions.
A subset of participants completed a 12-week high-intensity interval training intervention.
Measurements assessed included D L,CO5s, V C, and others during upright-to-supine transitions.
Upright-to-supine change in D L,CO5s was significantly reduced in moderate (P < 0.001) and severe COPD (P = 0.006) compared to controls.
Pulmonary capillary blood volume response decreased in moderate (P < 0.001) and severe COPD (P = 0.021) compared to controls.
HIIT intervention did not influence pulmonary diffusing capacity metrics.

Rasmussen et al. (2026) studied this question.

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