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May 27, 2026JCEM Case Reports0 citationsOpen Access

Clinical and biochemical variability in composite pheochromocytomas: a report of 3 cases

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ALAudrey LeeSȘSimona ȘtefanRBRobert Berkenblit

Key Points

  • The aim is to highlight the clinical and biochemical variability of composite pheochromocytomas through case presentations.
  • Presentation of 3 individual cases of composite pheochromocytomas.
  • Analysis of clinical manifestations and biochemical data.
  • The cases illustrate diverse clinical presentations atypical for pheochromocytoma.
  • A high level of clinical suspicion is emphasized for accurate diagnosis due to their rarity.

Abstract

Abstract Composite pheochromocytomas are a rare subset of pheochromocytomas composed of chromaffin cell tumors and neurogenic tumors. Their clinical manifestations may be atypical for pheochromocytoma. Here, we present 3 cases that illustrate the broad spectrum of disease seen in composite pheochromocytomas. A high level of clinical suspicion is needed to diagnose composite pheochromocytomas given their rarity and diverse clinical presentations.

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Cite This Study

Lee et al. (2026) studied this question.

synapsesocial.com/papers/6a168b770c924ddd1bd5a3fdhttps://doi.org/10.1210/jcemcr/luag099
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