Telmisartan 80 mg combined with HCTZ 12.5 mg reduced supine trough diastolic blood pressure by 13.3 mmHg, providing greater antihypertensive activity than corresponding monotherapies (p<0.01).
RCT (n=222)
Double-blind
randomized
Does combination treatment with telmisartan and hydrochlorothiazide improve blood pressure reduction compared to monotherapy in black patients with mild to moderate hypertension?
Combination therapy with telmisartan and hydrochlorothiazide is effective and well-tolerated for blood pressure control in black patients with mild to moderate hypertension, providing greater efficacy than monotherapy.
p-value: p=< 0.01
BACKGROUND: Hydrochlorothiazide (HCTZ) is commonly used to treat black patients with hypertension. To avoid the metabolic disturbances associated with high-dose HCTZ, blood pressure control may be achieved by combining low doses with another antihypertensive. HYPOTHESIS: The study was undertaken to assess the tolerability and antihypertensive dose-response efficacy of telmisartan and HCTZ and their combination in black patients with mild to moderate hypertension (mean supine blood pressure 140/95-200/114 mmHg). METHODS: Following a 4-week, single-blind, placebo run-in period, 222 black patients were randomized to once-daily treatment with one of 20 different double-blind combinations of telmisartan (0, 20, 40, 80, 160 mg) and HCTZ (0, 6.25, 12.5, 25 mg) for 8 weeks. Blood pressure was measured at baseline and after 2, 4, and 8 weeks. RESULTS: Telmisartan 80 mg/HCTZ 12.5 mg reduced supine trough diastolic blood pressure (DBP)--primary efficacy parameter--by 13.3 mmHg, and supine trough systolic blood pressure (SBP) by 21.5 mmHg. These reductions represented benefits of 13.7/8.7 mmHg over telmisartan 80 mg and 12.3/8.1 mmHg over HCTZ 12.5 mg (p < 0.01). Telmisartan 40 mg/HCTZ 12.5 mg reduced supine trough SBP/DBP by 14.3/10.0 mmHg, amounting to 12.3/3.3 mmHg more than telmisartan 40 mg and 5.1/4.8 mmHg more than HCTZ 12.5 mg. This reached significance for the comparisons with telmisartan 40 mg for SBP and HCTZ 12.5 mg for DBP (p<0.05). A response surface analysis and therapeutic response rates confirmed the additive antihypertensive effects of telmisartan and HCTZ. All treatments were well tolerated, with side-effect profiles comparable with placebo. Adverse events were mainly transient and of mild to moderate severity. CONCLUSIONS: Telmisartan 80 mg combined with HCTZ 12.5 mg is effective and well tolerated in black patients with mild to moderate hypertension, providing greater antihypertensive activity than the corresponding monotherapies.
McGill et al. (2001) conducted an RCT in mild to moderate hypertension (n=222). telmisartan and hydrochlorothiazide (HCTZ) vs. monotherapies and placebo was evaluated on supine trough diastolic blood pressure (DBP) (p=< 0.01). Telmisartan 80 mg combined with HCTZ 12.5 mg reduced supine trough diastolic blood pressure by 13.3 mmHg, providing greater antihypertensive activity than corresponding monotherapies (p<0.01).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: