Key result
Telmisartan 80 mg combined with HCTZ 12.5 mg reduced supine trough diastolic blood pressure by 13.3 mmHg, providing greater antihypertensive activity than corresponding monotherapies (p<0.01).
Why the study?
Does combination treatment with telmisartan and hydrochlorothiazide improve blood pressure reduction compared to monotherapy in black patients with mild to moderate hypertension?
Population
222 black patients with mild to moderate hypertension (mean supine blood pressure 140/95-200/114 mmHg)
Comparison
Once-daily treatment with one of 20 different… vs Corresponding monotherapies or placebo
Design
RCT, Randomized to once-daily treatment with one of 20 different double-blind…
Follow-up
8 weeks
Authors
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Supports telmisartan-HCTZ combination for superior BP control in black patients; extends RCT data on fixed-dose regimens beyond monotherapy.
RCT (n=222)
Double-blind
randomized
Does combination treatment with telmisartan and hydrochlorothiazide improve blood pressure reduction compared to monotherapy in black patients with mild to moderate hypertension?
p-value: p=< 0.01
Combination therapy with telmisartan and hydrochlorothiazide is effective and well-tolerated for blood pressure control in black patients with mild to moderate hypertension, providing greater efficacy than monotherapy.
McGill et al. (2001) conducted an RCT in mild to moderate hypertension (n=222). telmisartan and hydrochlorothiazide (HCTZ) vs. monotherapies and placebo was evaluated on supine trough diastolic blood pressure (DBP) (p=< 0.01). Telmisartan 80 mg combined with HCTZ 12.5 mg reduced supine trough diastolic blood pressure by 13.3 mmHg, providing greater antihypertensive activity than corresponding monotherapies (p<0.01).
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