Why the study?
Does combination therapy with telmisartan and hydrochlorothiazide reduce early morning blood pressure in uncontrolled hypertensive patients on ARB therapy?
Does combination therapy with telmisartan and hydrochlorothiazide reduce early morning blood pressure in uncontrolled hypertensive patients on ARB therapy?
Switching to a combination of telmisartan and low-dose hydrochlorothiazide effectively reduces early morning blood pressure in patients uncontrolled on standard ARB therapy.
Supports switching ARB-uncontrolled patients to telmisartan-hydrochlorothiazide for morning BP control; extends RCT evidence on fixed-dose ARB-diuretic combinations.
Hypertensive patients whose BP was uncontrolled despite the use of antihypertensive agents, including an ARB (candesartan 8 mg/day or valsartan 80 mg/day), were enrolled. The patients were randomly assigned to combination therapy with telmisartan 40 mg/day (changed from current ARB) and hydrochlorothiazide (HCTZ) 12.5 mg/day (T + H, n = 32) or to no change in their current drug regimen (CTL, n = 32). The observation period was 12 weeks. The office and home BPs were significantly reduced in the T + H compared to those in the CTL. A sufficient and long-acting BP lowering effect, as reflected in decreased early morning BP, was obtained with the combination of low-dose HCTZ and telmisartan without apparent metabolic deterioration.
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Makita et al. (2009) studied this question.
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