What question did this study set out to answer?

This research aims to create a microfluidic device to simulate traumatic brain injury effects on brain cells.

May 28, 2026Lab on a Chip0 citations

Traumatic brain injury on-a-chip: a microfluidic device for the compression of cortical spheroids

MCMauricio David Araiza CanizalesUniversity of Wisconsin–Madison AMAlexander McGheeUniversity of Arizona YWYang WanBrown University

Key Points

This research aims to create a microfluidic device to simulate traumatic brain injury effects on brain cells.
Developed a microfluidic platform for mimicking injury conditions on cortical spheroids.
Utilized controlled compression to assess cellular responses under TBI-like conditions.
Observed changes in cell viability and morphology after compression, indicating injury effects.
Quantified response variability in cortical spheroids due to different levels of applied force.

Abstract

Traumatic brain injury (TBI) affects more than 4.6 million people annually in the United States, with the true numbers of mild TBI (mTBI) likely much higher due to insufficient detection...

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