What question did this study set out to answer?

To review the utility and integration of multiscale imaging techniques and molecular probes within systems biology, with a focus on cancer targeting applications.

August 12, 2008BMC Systems Biology306 citationsOpen Access

A review of imaging techniques for systems biology

AKArmen R. KherlopianCornell University TSTing SongShanxi Medical University QDQi DuanGuangdong University of Technology

Key Points

To review the utility and integration of multiscale imaging techniques and molecular probes within systems biology, with a focus on cancer targeting applications.
Reviewed and compared imaging modalities including optical microscopy, ultrasound, computed tomography (CT), magnetic resonance imaging (MRI), and positron emission tomography (PET).
Evaluated the integration of nanoscale molecular probes, specifically quantum dots and nanoshells, for targeted molecular and cellular imaging.
Demonstrated how complementary imaging technologies span micro-to-macro scales to bridge experimental observations and mathematical systems modeling.
Highlighted cancer targeting as a unifying biological paradigm effectively characterized by combining anatomical, functional, and molecular imaging modalities.

Abstract

This paper presents a review of imaging techniques and of their utility in system biology. During the last decade systems biology has matured into a distinct field and imaging has been increasingly used to enable the interplay of experimental and theoretical biology. In this review, we describe and compare the roles of microscopy, ultrasound, CT (Computed Tomography), MRI (Magnetic Resonance Imaging), PET (Positron Emission Tomography), and molecular probes such as quantum dots and nanoshells in systems biology. As a unified application area among these different imaging techniques, examples in cancer targeting are highlighted.

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