DPP3 deficiency impacts bone quality and sensitizes to metabolic alterations

Key Points

• This research aims to investigate how DPP3 deficiency affects bone quality and metabolic responses to dietary influences.
• Utilized a high-fat diet (HFD) to analyze DPP3 protein levels in young wild-type (WT) and DPP3 knockout (ko) male and female mice.
• Conducted multivariate analysis to assess changes in serum DPP3 concentration and activity ratio, along with bone volume and biomechanical parameters.
• Compared metabolic markers, glucose tolerance, and bone properties between Dpp3 ko and WT mice.
• Serum DPP3 levels significantly decreased in young male WT mice on HFD, while females showed no change.
• Bone volume (BV/TV) was lower in Dpp3 ko compared to WT male mice, unaffected by diet.
• Significant differences were observed in biomechanical parameters under multivariate analysis, indicating varying resistance to damage.