Cardiovascular events and all-cause mortality in surgically or medically treated primary aldosteronism: A Meta-analysis

OBJECTIVES: To compare the effect of surgical or medical treatment on the risk of cardiovascular diseases (CVD) and all-cause mortality in patients with established primary aldosteronism (PA). METHODS: We searched PUBMED, MEDLINE and Cochrane Library for the meta-analysis. We included patients who were diagnosed with PA following guideline-supported protocols and received surgery or mineralocorticoid receptor antagonist (MRA)-based medical treatment, and age-sex matched patients with treated essential hypertension (EH). Primary endpoints were CVD incidence and all-cause mortality. RESULTS: Compared with EH, patients with treated PA had a higher risk of CVD odds ratio (OR) 1.79; 95% confidence interval (CI) 1.39-2.31. This elevated risk was only observed in patients with medically treated PA OR 2.11; 95%CI 1.88-2.38 but not in those with surgically treated PA. The risk of all-cause mortality was significantly lower in patients with treated PA OR 0.86; 95% CI 0.77-0.95 compared to EH. The reduced risk was only observed in patients with surgically treated PA OR 0.47; 95% CI 0.34-0.66, but not in those with medically treated PA. CONCLUSIONS: Patients with medically treated PA have a higher risk of CVD compared to patients with EH. Surgical treatment of PA reduces the risk of CVD and all-cause mortality in patients with PA.