Visible-Light-Mediated Installation of Unactivated Alkyl Groups Enabling Access to Non-Natural Amino Acid Derivatives: Detailed Mechanistic Insights

Key Points

• To explore a method for synthesizing non-natural amino acid derivatives via visible-light-driven alkylation using silanes.
• Employs visible-light-driven alkylation of electron-deficient olefins using tris(trimethylsilyl)silane (TTMS) as a reagent.
• Investigates mechanistic insights into the alkylation process and its efficiency.
• Utilizes unactivated halides as starting materials for the synthesis.
• Achieves successful alkylation of various electron-deficient olefins.
• Demonstrates the potential of using unactivated halides for synthesizing non-natural amino acid derivatives.
• Reports detailed mechanistic insights contributing to the understanding of the reaction efficiency and conditions.