Copper-coordinated dendritic photosensitizer for spatiotemporally synergistic PDT-CDT cascade antitumor therapy

Key Points

• This research aims to develop a novel copper-coordinated dendritic photosensitizer for effective antitumor therapy through dual mechanisms.
• Utilized a copper-coordinated dendritic photosensitizer (TPAGP@Cu).
• Integrated photodynamic therapy (PDT) and chemodynamic therapy (CDT) via dual mechanisms.
• Focused on GSH-depleting Fenton-like chemistry for enhanced oxidative therapy.
• TPAGP@Cu significantly increased oxidative stress in tumor cells.
• Demonstrated superior antitumor effects compared to traditional methods.