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May 31, 2026Chemical Communications0 citations

Copper-coordinated dendritic photosensitizer for spatiotemporally synergistic PDT-CDT cascade antitumor therapy

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YXYuqin XuJCJiaxin ChengDLDong Liu

Key Points

  • This research aims to develop a novel copper-coordinated dendritic photosensitizer for effective antitumor therapy through dual mechanisms.
  • Utilized a copper-coordinated dendritic photosensitizer (TPAGP@Cu).
  • Integrated photodynamic therapy (PDT) and chemodynamic therapy (CDT) via dual mechanisms.
  • Focused on GSH-depleting Fenton-like chemistry for enhanced oxidative therapy.
  • TPAGP@Cu significantly increased oxidative stress in tumor cells.
  • Demonstrated superior antitumor effects compared to traditional methods.

Abstract

TPAGP@Cu: a copper-coordinated dendritic photosensitizer integrating PDT and CDT via dual Type I/II mechanisms and GSH-depleting Fenton-like chemistry for spatiotemporally amplified oxidative antitumor therapy.

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Cite This Study

Xu et al. (2026) studied this question.

synapsesocial.com/papers/6a1bd2375783ba022b6fd9fchttps://doi.org/10.1039/d6cc01439a
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