Discovery of Imidazo1, 2- a pyridine Hydrazone Derivatives as Novel Antifungal Tubulin-Targeting Agents via a Scaffold-Hopping Strategy

Key Points

• This research aims to identify new antifungal agents that target tubulin using a scaffold-hopping strategy.
• Investigated the interactions of imidazo[1,2-a]pyridine hydrazone derivatives with tubulin.
• Examined the effects of compounds on microtubule aggregation and hyphal morphology.
• Evaluated cellular architecture disruption caused by these derivatives.
• Compounds formed multiple hydrogen bonds and π-π interactions with tubulin.
• Induced significant microtubule aggregation in treated cells, impacting hyphal morphology.
• Demonstrated potential for overcoming limitations in existing antifungal therapies.