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June 1, 20260 citationsOpen Access

Anti-Arthritic and Osteoarthritis Activity of Drypetes Roxburghii Leaves on Some Different Solvent Extract

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DDDr. Arvind Jowar*, Dr. Vikash Gupta1, Rashmi Chourasiya2, Sonal Dixit3

Key Points

  • This study aims to evaluate the antioxidant and anti-arthritic properties of Drypetes roxburghii leaf extracts.
  • Determined total phenolic and flavonoid contents using Folin-Ciocalteu and aluminum chloride methods.
  • Assessed in vitro antioxidant potential via DPPH radical scavenging assay.
  • Investigated in vivo anti-arthritic activity using a CFA-induced arthritis rat model.
  • D. roxburghii extract showed moderate antioxidant potential with an IC50 value of 87.80 µg/mL.
  • At 100 mg/kg and 200 mg/kg, treatments significantly reduced paw volume to 0.60±0.031 mL and 0.51±0.045 mL, respectively (p < 0.05).
  • The inflammation reduction was comparable to diclofenac sodium at 5 mg/kg, which had a paw volume of 0.49±0.050 mL.

Abstract

Background p < 0.05) compared to the control group. This reduction in inflammation was comparable to the standard reference drug, diclofenac sodium (5 mg/kg; 0.49±0.050 mL). Conclusion: The findings indicate that the ethanolic leaf extract of D. roxburghii possesses significant antioxidant properties and effective dose-dependent anti-arthritic activity, supporting its potential therapeutic use in managing inflammatory joint diseases.

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Cite This Study

Dr. Arvind Jowar*, Dr. Vikash Gupta1, Rashmi Chourasiya2, Sonal Dixit3 (2026) studied this question.

synapsesocial.com/papers/6a1d236002fbce9130638f9ahttps://doi.org/10.5281/zenodo.20456798
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