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March 17, 2026Frontiers in Pediatrics0 citationsOpen Access

Case Report: MIS-C precipitating DKA and renal failure in a morbidly obese male with type 2 diabetes mellitus

JTJohn TumbergerVCVincent CzerwinskiFMFrancesca Pérez Marquès

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Abstract

Multisystem inflammatory syndrome in children (MIS-C) is a recently described systemic inflammatory sequelae of SARS-CoV-2 infection. Diagnostic criteria for MIS-C includes age 38°C), laboratory evidence of inflammation, clinically severe illness requiring hospitalization with multisystem (≥2) organ involvement, Evidence of current or recent SARS-CoV-2 infection or exposure, and has no alternative explanation for their symptoms. We present a 15-year-old, morbidly obese male whose diagnosis of MIS-C was obfuscated by diabetic ketoacidosis (DKA). This case highlights the increased risk of development of MIS-C in obese children, variability of presentation, and contributes to the body of research demonstrating endocrinologic complications of MIS-C.

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Tumberger et al. (2026) studied this question.

synapsesocial.com/papers/6a1ed2dc302206c0d07e7fe6https://doi.org/10.3389/fped.2026.1727955
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