Significance: Photothermal therapy is a minimally invasive technique that utilizes near-infrared light to induce localized hyperthermia for the selective ablation of cancer cells. Its therapeutic efficacy is highly dependent on precise temperature regulation. Aiming at the problems of invasiveness, insufficient penetration depth existing in current temperature monitoring technologies, we propose an innovative solution. Aim: biological tissues during laser heating. Approach: By constructing an optothermal-acoustic multiphysics coupling model and combining it with our designed dual-optical path co-coupled photoacoustic-photothermal temperature monitoring system, noninvasive observation of the internal heat source distribution in tissues is achieved. On this basis, theoretical data and real data are fused to realize precision measurement of the temperature in the lesion area and adjacent tissues. Result: tissues at the millimeter to centimeter depth range, and the temperature measurement error at multiple different validation sampling points is within 0.25°C. Conclusion: tissues during laser heating, offering a broader temperature measurement range compared with conventional photoacoustic thermometry. This method possesses certain academic value and is expected to provide technical reference for the research on target temperature sensing during photothermal treatment.
Han et al. (Fri,) studied this question.