An exaggerated blood pressure response to light exercise was independently associated with a higher likelihood of increased urinary albumin excretion (OR 1.51; 95% CI 1.10-2.08; p=0.01).
Observational (n=8,631)
Is an exaggerated blood pressure response to light exercise associated with increased urinary albumin excretion in non-diabetic individuals with non-elevated resting blood pressure?
In non-diabetic individuals with normal resting blood pressure, an exaggerated blood pressure response to light exercise is associated with a 51% increased odds of elevated urinary albumin excretion, suggesting early subclinical target organ damage.
Odds Ratio: 1.51 (95% CI 1.1–2.08)
p-value: p=0.01
Objective: Increased urinary albumin excretion (UAE) is a prognostic marker of kidney disease in patients with hypertension or diabetes. An exaggerated blood pressure (BP) response to light exercise is a predictor of future development of hypertension in non-hypertensive individuals. However, the association between exercise BP and UAE in non-diabetic individuals with non-elevated BP remains unclear. We investigated whether higher exercise BP is associated with increased UAE in this population. Design and method: This is a retrospective registry-based observational study. Among non-diabetic individuals with non-elevated resting BP (systolic BP = 20 mmHg at stage 1 of the exercise test. Increased UAE was defined as an ACR >= 30 mg/mmol. Results: The mean age was 48 ± 8 years, and 81% of participants were male. An exaggerated BP response was observed in 25% of subjects, while increased UAE was present in 3%. An exaggerated BP response was independently associated with a higher likelihood of increased UAE (odds ratio 1.51, 95% confidence interval 1.10–2.08; p = 0.01) after adjustment for age, sex, resting systolic BP, body mass index, and hemoglobin A1c. Conclusions: In individuals with non-elevated resting BP, an exaggerated BP response to light exercise was associated with increased UAE. Exercise BP response may serve as a useful marker of masked hypertension and subclinical target organ damage.
Sung et al. (Fri,) conducted a observational in Non-diabetic individuals with non-elevated resting blood pressure (n=8,631). Exaggerated blood pressure response to light exercise vs. Normal blood pressure response to light exercise was evaluated on Increased urinary albumin excretion (ACR >= 30 mg/mmol) (OR 1.51, 95% CI 1.10-2.08, p=0.01). An exaggerated blood pressure response to light exercise was independently associated with a higher likelihood of increased urinary albumin excretion (OR 1.51; 95% CI 1.10-2.08; p=0.01).