Integrative multi-omics Mendelian randomization reveals key lipid metabolism genes as therapeutic targets for diabetic nephropathy pathogenesis

Key Points

• The aim is to identify lipid metabolism genes linked to diabetic nephropathy through Mendelian randomization techniques.
• The study employs integrative multi-omics and Mendelian randomization methodologies.
• Data integration from genomic, transcriptomic, and metabolomic analyses was utilized to infer causal relationships.
• Findings reveal discordance between genetically inferred risks and observed gene expression patterns.
• Indications of complex regulatory mechanisms affecting lipid metabolism genes in diabetic nephropathy were identified.