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June 3, 2026Organic & Biomolecular Chemistry0 citationsOpen Access

Synthesis of uniflorol B, a chromanone metabolite of Calea uniflora, and investigation of novel analogues as anti-leishmanial agents

LNLuana Budny NieroDLDaniela P LageFCFerraz Coelho

Key Points

  • The aim is to synthesize uniflorol B and explore its analogues for anti-leishmanial activity.
  • First synthesis of uniflorol B from Calea uniflora
  • Investigation of novel analogues
  • Evaluation of anti-leishmanial properties in vitro
  • Uniflorol B synthesized successfully, providing a template for further research
  • Analogue compounds show promising anti-leishmanial activity, indicating potential therapeutic use

Abstract

In this work, we report the first synthesis of the anti-leishmanial natural product uniflorol B. Uniflorol B is a chromanone metabolite first isolated from the Brazilian medicinal plant Calea uniflora...

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Cite This Study

Niero et al. (2026) studied this question.

synapsesocial.com/papers/6a1fc509dee9eb8c0dce6714https://doi.org/10.1039/d6ob00708b
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