The aim is to synthesize uniflorol B and explore its analogues for anti-leishmanial activity.
First synthesis of uniflorol B from Calea uniflora
Investigation of novel analogues
Evaluation of anti-leishmanial properties in vitro
Uniflorol B synthesized successfully, providing a template for further research
Analogue compounds show promising anti-leishmanial activity, indicating potential therapeutic use
Abstract
In this work, we report the first synthesis of the anti-leishmanial natural product uniflorol B. Uniflorol B is a chromanone metabolite first isolated from the Brazilian medicinal plant Calea uniflora...