Head-up tilt to 60° caused a greater increase in finger-toe pulse wave velocity (6.2 to 10.1 m/s) than in carotid-femoral pulse wave velocity (7.9 to 8.8 m/s; both P<0.001).
Cross-Sectional (n=90)
Does head-up tilt to 60° differentially affect carotid–femoral and finger–toe pulse wave velocity in adults?
Finger-toe pulse wave velocity shows a more pronounced increase than carotid-femoral pulse wave velocity in response to hydrostatic loading, suggesting a stronger contribution from muscular, medium- to small-sized arteries.
p-value: p=<0.001
Objective: To compare the responses of carotid–femoral pulse wave velocity (CF-PWV) and finger–toe pulse wave velocity (FT-PWV) to hydrostatic loading induced by head-up tilt from the horizontal position to 60° in adults with and without cardiometabolic or chronic kidney disease. Design and method: Aortic stiffness is classically assessed by carotid–femoral pulse wave velocity (CF-PWV) measured in the supine position to minimize hydrostatic pressure gradients. Finger-to-toe pulse wave velocity (FT-PWV), derived from photoplethysmography signals, correlates well with CF-PWV but integrates arterial segments ranging from large elastic arteries to medium- and small-sized vessels. The present study aimed to compare the responses of CF-PWV and FT-PWV to hydrostatic loading induced by head-up tilt from the horizontal position to 60°. This is a cross-sectional study involving adult population with or without cardiovascular disease, diabetes or chronic kidney disease. CF-PWV was determined by Complior SP and FT-PWV was determined by pOpmetre in triplicates both in supine and at 60° after a period of 5 minutes of rest in this position. Results: Among 90 participants (age 47 ± 19 years; 51% female), 16% had diabetes, 32% hypertension, 8% cardiovascular disease, and 13% chronic kidney disease. With head-up tilt, systolic blood pressure decreased (126 ± 14 to 122 ± 13 mmHg; P = 0.004), whereas diastolic blood pressure and heart rate increased (79 ± 11 to 81 ± 10 mmHg; P = 0.02 and 65 ± 9 to 78 ± 16 beats/min; P < 0.001). CF-PWV increased modestly (7.9 ± 1.9 to 8.8 ± 2.6 m/s; P < 0.001), while FT-PWV showed a more pronounced increase (6.2 ± 1.9 to 10.1 ± 3.6 m/s; P < 0.001). CF-PWV and FT-PWV were moderately correlated in both the horizontal (r = 0.62) and 60° positions (r = 0.52), with no significant difference between correlation coefficients. Conclusions: The greater increase in FT-PWV in response to hydrostatic loading, accompanied by an increase in heart rate as a marker of sympathetic activation, suggests a stronger contribution from more muscular, medium- to small-sized arteries to the observed rise in PWV.
Khataei et al. (Fri,) conducted a cross-sectional in Cardiometabolic or chronic kidney disease (n=90). Head-up tilt to 60° vs. Horizontal/supine position was evaluated on Response of carotid-femoral (CF-PWV) and finger-toe pulse wave velocity (FT-PWV) to head-up tilt (p=<0.001). Head-up tilt to 60° caused a greater increase in finger-toe pulse wave velocity (6.2 to 10.1 m/s) than in carotid-femoral pulse wave velocity (7.9 to 8.8 m/s; both P<0.001).