Selective 1,2-addition of acetonitrile/acetone to α,β-unsaturated aldehydes at room temperature: access to cinnamyl alcohol derivatives with potential protective effects against exercise-induced skeletal muscle injury

Key Points

• The aim is to explore a selective method for synthesizing cinnamyl alcohol derivatives with potential benefits for muscle injury recovery.
• Developed an electrocatalytic 1,2-addition process at room temperature.
• Synthesized 38 cinnamyl alcohol derivatives in mild reaction conditions.
• Successful production of 38 different cinnamyl alcohol derivatives.
• Demonstrated potential protective effects against exercise-induced skeletal muscle injury.