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June 3, 2026Journal of Environmental Science and Health Part B0 citations

Targeting Fusarium oxysporum with pineapple, papaya, and watermelon peel extract: binding to SIX8 protein and in vitro efficacy

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IHIda HodiyahRPRudi PriyadiEHElya Hartini

Key Points

  • The aim is to evaluate the antifungal potential of pineapple, papaya, and watermelon peel extracts against Fusarium oxysporum.
  • Conducted broth microdilution assays to determine Minimum Inhibitory Concentration (MIC) of fruit peel extracts.
  • Assessed the binding of extracts to SIX8 protein.
  • Evaluated the potency of papaya, pineapple, and watermelon peel extracts.
  • Papaya peel extract demonstrated the highest potency with a MIC of 10% v/v.
  • Pineapple and watermelon peel extracts required a higher MIC of 40% v/v.
  • Study indicates multicomponent synergy in papaya peel extract despite lower single-metabolite docking rankings.

Abstract

broth microdilution assays revealed that papaya peel extract was the most potent, with a Minimum Inhibitory Concentration (MIC) of 10% v/v, while pineapple and watermelon required 40% v/v. The superior potency of papaya, despite lower single-metabolite docking rankings, suggests multicomponent synergy and matrix effects. These findings indicate that SIX8 is a ligandable target and that fruit peel phytochemicals function as effective antifungal agents.

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Cite This Study

Hodiyah et al. (2026) studied this question.

synapsesocial.com/papers/6a1fc6cddee9eb8c0dce7a73https://doi.org/10.1080/03601234.2026.2679393
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