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June 3, 2026Pediatric Allergy and ImmunologyOpen Access

Central precocious puberty and risk of atopic diseases: The mediating role of obesity and sex hormones

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Authors

YLYung-Han LaiYLYu Hsiang LiuHCHsiao‐Chi Chuang

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Overview

Randomized trial examines the link between central precocious puberty and atopic diseases, indicating obesity's mediating role.

Key Points

  • This research aims to understand how central precocious puberty (CPP) relates to atopic diseases through obesity and sex hormones.
  • Data analyzed from the Taiwan Pubertal Longitudinal Study (2018-2021; n=2317)
  • Participants included adolescents aged 6-15 years with confirmed CPP and physician-diagnosed atopic diseases
  • Logistic regression and structural equation modeling utilized for analysis.
  • Obesity significantly increased the risk of atopic diseases among children with CPP, especially in boys.
  • Testosterone showed a protective effect against asthma in the overall cohort, notably in boys.
  • Only obesity directly mediated the connection between CPP and atopic diseases.

Cite This Study

Lai et al. (2026) studied this question.

synapsesocial.com/papers/6a1fc756dee9eb8c0dce82cbhttps://doi.org/10.1111/pai.70355
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