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June 3, 2026Pediatric Allergy and ImmunologyOpen Access

Central precocious puberty and risk of atopic diseases: The mediating role of obesity and sex hormones

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Authors

YLYung-Han LaiYLYu Hsiang LiuHCHsiao‐Chi Chuang

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Overview

Randomized trial examines the link between central precocious puberty and atopic diseases, indicating obesity's mediating role.

Key Points

  • This research aims to understand how central precocious puberty (CPP) relates to atopic diseases through obesity and sex hormones.
  • Data analyzed from the Taiwan Pubertal Longitudinal Study (2018-2021; n=2317)
  • Participants included adolescents aged 6-15 years with confirmed CPP and physician-diagnosed atopic diseases
  • Logistic regression and structural equation modeling utilized for analysis.
  • Obesity significantly increased the risk of atopic diseases among children with CPP, especially in boys.
  • Testosterone showed a protective effect against asthma in the overall cohort, notably in boys.
  • Only obesity directly mediated the connection between CPP and atopic diseases.

Cite This Study

Lai et al. (2026) studied this question.

synapsesocial.com/papers/6a1fc756dee9eb8c0dce82cbhttps://doi.org/10.1111/pai.70355
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Transitions in stress, depression, and self-esteem across pubertal onset in children with central precocious puberty2026
  2. 2Breastfeeding, Prepubertal Adiposity, and Development of Precocious Puberty2025
  3. 3Trend in Body Mass Index During Childhood in 460 Girls with Idiopathic Central Precocious Puberty2025
  4. 4Investigation of the emotional and psychosocial dimensions of girls diagnosed with ıdiopathic central precocious puberty.2026
  5. 5Does precocious puberty and its treatment cause the emotional and behavioural problems in children?2024