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August 21, 2025JAMA Network OpenOpen Access

Breastfeeding, Prepubertal Adiposity, and Development of Precocious Puberty

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Authors

YCYunsoo ChoeSRSoorack RyuJCJinjoo Choi

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Overview

Retrospective cohort study reveals breastfeeding lowers risk of central precocious puberty, implying nutrition's role in development.

Key Points

  • Breastfeeding in the first 4 to 6 months lowers the risk of central precocious puberty in both boys and girls.
  • Formula-fed children had a higher risk of precocious puberty, with adjusted hazard ratios of 1.16 for boys and 1.60 for girls.
  • Retrospective cohort analysis utilized data from 322,731 children, assessing associations between feeding practices and puberty onset.
  • Findings highlight that early-life nutrition plays a critical role in pubertal timing, with prepubertal adiposity partially mediating the association.

Cite This Study

Choe et al. (2025) studied this question.

synapsesocial.com/papers/68a6fb9b5502675167ba94efhttps://doi.org/10.1001/jamanetworkopen.2025.27455
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