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October 1, 2001Angewandte Chemie International Edition196 citations

DNA-Directed Functionalization of Colloidal Gold with Proteins This work was supported by Deutsche Forschungsgemeinschaft and Fonds der Chemischen Industrie. We thank Prof. D. Blohm for helpful discussions and generous support.

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CNChristof M. NiemeyerBCBülent Ceyhan

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Abstract

A supramolecular construction kit comprises DNA-functionalized gold nanoparticles, covalent DNA–streptavidin conjugates, and biotinylated antibodies and allows the generation of functional nanoparticle reagents (see schematic illustration). The combination of specific antibodies and DNA-stabilized colloidal gold is applicable for the detection of antigens attached to a chip.

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Niemeyer et al. (2001) studied this question.

synapsesocial.com/papers/6a1ff99f31a4466a462e41b3https://doi.org/10.1002/1521-3773(20011001)40:19<3685::aid-anie3685>3.0.co;2-e
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