Zinc Metabolism in Hepatic Dysfunction

Article1 May 1959ZINC METABOLISM IN HEPATIC DYSFUNCTIONBERT L. VALLEE, M.D., WARREN E. C. WACKER, M.D., ANTHONY F. BARTHOLOMAY, SC.D., FREDERIC L. HOCH, M.D.BERT L. VALLEE, M.D., WARREN E. C. WACKER, M.D., ANTHONY F. BARTHOLOMAY, SC.D., FREDERIC L. HOCH, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-50-5-1077 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptZinc is present in all living organisms and is essential as a nutrient for plants and animals.13, 27The normal human dietary intake of zinc is about 10 to 15 mg. a day. The stool is the major excretory route; it contains about 10 mg. a day, whereas the urine contains only about 0.4 to 0.5 mg. a day.17The amount of zinc in different human organs varies between 10 and 200 μg. per gram of wet tissue.30The human liver contains 50 to 60 μg. of zinc per gram.34The identification of zinc as a component of carbonic anhydrase...Bibliography1. Bliss AF: Equilibrium between vitamin A alcohol and aldehyde in the presence of alcohol dehydrogenase, Arch. Biochem. 31: 197, 1951. CrossrefMedlineGoogle Scholar2. Bonnichsen RK: Crystalline animal alcohol dehydrogenase, Acta chem. Scand. 4: 715, 1950. CrossrefGoogle Scholar3. BownessMortonShakirStubbs JMRAMHAL: Distribution of copper and zinc in mammalian eyes. Occurrence of metals in melanin fractions from eye tissues, Biochem. J. 51: 521, 1952. CrossrefMedlineGoogle Scholar4. Ershoff BH: Conditioning factors in nutritional disease, Physiol. Rev. 28: 107-137, 1948. CrossrefMedlineGoogle Scholar5. 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ValleeWackerBartholomayRobin BLWEAFED: Zinc metabolism in hepatic dysfunction. I. Serum zinc concentrations in Laennec's cirrhosis and their validation by sequential analysis, New England J. Med. 255: 403, 1956. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: BERT L. VALLEE, M.D.; WARREN E. C. WACKER, M.D.; ANTHONY F. BARTHOLOMAY, SC.D.; FREDERIC L. HOCH, M.D.*Received for publication January 16, 1959.Presented at the Thirty-ninth Annual Session of The American College of Physicians, Atlantic City, New Jersey, May 2, 1958.From the Biophysics Research Laboratory and the Medical Clinic, Department of Medicine, Harvard Medical School and Peter Bent Brigham Hospital.†Supported by the Lasdon Fund, the Hartford Fund, the Rockefeller Foundation and the Howard Hughes Medical Institute.Requests for reprints should be addressed to Bert L. Vallee, M.D., Biophysics Research Laboratory of the Department of Medicine, Peter Bent Brigham Hospital, 721 Huntington Avenue, Boston 15, Massachusetts. 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