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OBJECTIVE: This systematic review and meta-analysis aimed to evaluate the effectiveness of interventions for increasing lung cancer screening (LCS) uptake and to identify factors influencing their implementation. METHODS: We searched MEDLINE, CINAHL, EMBASE, Cochrane Library, and Web of Science from January 2010 to November 2025. Included studies were randomized controlled trials involving high-risk adults eligible for LCS with low-dose computed tomography, evaluating interventions to improve screening uptake as a primary or secondary outcome. RESULTS: Eleven trials were included, primarily from the United States (N = 9). Interventions were categorized as patient navigation, decision aids, educational video/film, targeted invitation/outreach, and multi-component intervention. Overall, interventions showed a modest but significant effect on LCS uptake (RR = 1.34; 95 % CI: 1.02, 1.76). The multi-component intervention (RR = 2.11; 95 % CI: 1.21, 3.68) demonstrated significant effects, while patient navigation showed potential (RR = 2.18; 95 % CI: 0.53, 9.08). Innovation and inner setting were identified as potentially important factors influencing intervention implementation. CONCLUSIONS: Interventions modestly increased LCS uptake, with multi-component intervention and patient navigation showing the most promising effects. Future research should prioritize multicomponent strategies that address the entire screening continuum, equity-focused designs for priority populations, and trials in diverse international settings.
Tao et al. (Tue,) studied this question.