A negative interventricular pressure gradient between the left and right ventricles during diastole was found to cause diastolic bulging of the interventricular septum toward the left ventricle.
Observational (n=4)
Does a negative interventricular pressure gradient cause diastolic bulging of the interventricular septum toward the left ventricle in patients with pulmonary hypertension?
Diastolic bulging of the interventricular septum toward the left ventricle on echocardiography is a reliable manifestation of a negative interventricular pressure gradient during diastole, typically seen in right ventricular hypertension.
Diastolic bulging of the interventricular septum (IVS) toward the left ventricle was observed by real-time cross-sectional echocardiography in three patients with primary pulmonary hypertension and one patient with secondary pulmonary hypertension after closure of an atrial septal defect. M-mode echocardiography showed a characteristic abnormal pattern of septal motion in diastole and in systole. In two patients, we attempted to correlate M-mode motion to the interventricular pressure gradient. During diastole, the interventricular pressure gradient between the left and right ventricles was negative and the pressure gradient curve was very similar to the M-mode echogram of the IVS. Banding studies in which acute right ventricular hypertension was produced in dogs showed similar shape changes, suggesting that the diastolic shape and motion of the septum are determined by the interventricular pressure gradient between the ventricles. Diastolic bulging of the IVS toward the left ventricle in our patients results from negative interventricular pressure gradient between the left and right ventricles during diastole.
Tanaka et al. (1980) conducted an observational in Pulmonary hypertension (n=4). Negative interventricular pressure gradient was evaluated on Diastolic bulging of the interventricular septum toward the left ventricle. A negative interventricular pressure gradient between the left and right ventricles during diastole was found to cause diastolic bulging of the interventricular septum toward the left ventricle.