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This study evaluates the morphological, mechanical, and antimicrobial properties of silk sutures coated with curcumin and honey extract compared to plain silk sutures.

June 4, 20260 citationsOpen Access

In Vitro Comparison of Morphological and Mechanical Properties, and Antimicrobial Efficacy of Silk Sutures Coated with Curcumin and Honey Extract

LCLakshmi Rathan Aarasoor Cunniah SNSuryakala Nadarajan VNV Narayanan

Key Points

This study evaluates the morphological, mechanical, and antimicrobial properties of silk sutures coated with curcumin and honey extract compared to plain silk sutures.
In vitro study with three groups of silk sutures: plain, curcumin-coated, and honey extract-coated (n=3).
Morphological assessment via scanning electron microscopy (SEM) and energy dispersive spectroscopy (EDS).
Tensile strength analyzed using straight-pull and knot-pull tests; antimicrobial efficacy measured using culture tests.
No significant difference in tensile strength among all groups (P=0.494 for straight pull, P=0.707 for knot pull).
Curcumin-coated sutures enhanced resistance to Pseudomonas aeruginosa (P=0.034).
Honey-coated sutures showed resistance to Escherichia coli (P=0.037) and exhibited excellent resilience.

Abstract

Background and Aim: Surgical sutures are necessary to achieve hemostasis at the surgical site and promote healing.Currently, antibiotic-coated sutures are used to inhibit bacterial adhesion and proliferation.However, they can lead to bacterial resistance.To overcome this issue, herbal-coated suture materials are employed.This study aimed to assess the morphological and mechanical properties and antimicrobial efficacy of plain silk sutures with suture material coated with curcumin and honey.Materials and Methods: This in vitro study included three groups (n=3).Group A consisted of plain silk sutures, group B consisted of silk sutures coated with curcumin, and group C consisted of silk sutures coated with honey extract.Morphological assessment was performed using scanning electron microscopy (SEM) and energy dispersive spectroscopy (EDS).Tensile strength was measured using straight-pull and knot-pull tests on a tensile tester, and antimicrobial efficacy was evaluated using antimicrobial culture tests for the three groups.Statistical analysis was carried out using SPSS version 22.0.Results: The morphology of coated sutures was validated by SEM images and EDS analysis.The tensile strength was not significantly different among the three groups, as assessed by the straight pull test (P=0.494)and knot pull test (P=0.707).Group A demonstrated no antibacterial activity.Group B demonstrated increased resistance to Pseudomonas aeruginosa (P.aeruginosa) (P=0.034), while Group C showed resistance to Escherichia coli (E.coli) (P=0.037). Conclusion:The results showed that honey-coated sutures were highly resilient and had excellent antimicrobial properties.Curcumin-coated sutures expressed less resilience with better antimicrobial properties.

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