Question 1

What does this research mean for the field?

Accepted Answer

Asymmetric deoxy-fluoroalkylation of amides can be achieved through transimination with Ellman's sulfinamide to form chiral sulfinimines, followed by diastereoselective fluoroalkylation. Novelty: ClaimNovelty.METHODOLOGICAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Question 2

What question did this study set out to answer?

Accepted Answer

To explore the impact of transimination on the formation of chiral sulfinimines and its application in diastereoselective fluoroalkylation.

Asymmetric Deoxy-Fluoroalkylation of Amides Enabled by Transimination

Key Points

Abstract

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