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June 4, 2026Radiology2 citationsOpen Access

Planimetric and Linear MRI Markers for Progressive Supranuclear Palsy Classification: A Large Multicohort International Study

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AQAndrea QuattroneAQAndrea QuattroneMBMaria Giovanna Bianco

Key Points

  • The study aims to evaluate the effectiveness of MRI markers in classifying progressive supranuclear palsy (PSP) compared to other neurodegenerative disorders.
  • Conducted a multicohort international study with large participant numbers.
  • Utilized planimetric and linear MRI markers for analysis.
  • Registration in clinical trials NCT03068468, NCT01110720, NCT01049399, NCT01804452.
  • The DMPI and midbrain area markers showed high effectiveness for differentiating PSP from other neurodegenerative parkinsonisms (AUC, 0.94 [95% CI: 0.86, 1.00]).

Abstract

= 43) (AUC, 0.94 95% CI: 0.86, 1.00). Conclusion The DMPI and midbrain area performed well for differentiating PSP from other neurodegenerative parkinsonisms. Clinical trial registration nos. NCT03068468, NCT01110720, NCT01049399, NCT01804452 © The Author(s) 2026. Published by the Radiological Society of North America under a CC BY 4.0 license.

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Cite This Study

Quattrone et al. (2026) studied this question.

synapsesocial.com/papers/6a2116cfd499ed480b16fb3dhttps://doi.org/10.1148/radiol.251394
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