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June 4, 2026RSC AdvancesOpen Access

Design, synthesis, and mechanistic evaluation of novel pyrazole/thiazole chalcone hybrids as dual tubulin polymerization and COX-2 inhibitors with potent antiproliferative activity

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Authors

BSBasima A. A. SALEEMAQAshraf A. QurtamASAbdelrahman R. Shalabi

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Overview

Randomized trial evaluates new chalcone hybrids for anticancer activity, suggesting potential therapies.

Key Points

  • This research aims to design and evaluate new pyrazole/thiazole chalcone hybrids as inhibitors of tubulin and COX-2 for cancer treatment.
  • Designed and synthesized a series of chalcone hybrids (9a–o)
  • Evaluated inhibitors' potency against tubulin polymerization and COX-2 activity
  • Assessed antiproliferative effects in cancer cells.
  • Identified novel hybrids with significant dual inhibition of tubulin polymerization and COX-2
  • Demonstrated potent antiproliferative activity compared to existing treatments.

Cite This Study

SALEEM et al. (2026) studied this question.

synapsesocial.com/papers/6a2116fad499ed480b16fe65https://doi.org/10.1039/d6ra03557d
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