A new kindred of patients with type III hyperlipoproteinemia was found to have no detectable plasma apolipoprotein E, suggesting the condition may be due to an absence or striking deficiency of apo E.
Case Report
Demonstrates that type III hyperlipoproteinemia can be associated with a complete absence of apolipoprotein E.
Subjects with type III hyperlipoproteinemia develop premature atherosclerosis and have hyperlipidemia due to an increase in cholesterol-rich very low density lipoproteins (VLDL) of abnormal electrophoretic mobility. Apolipoprotein E is a major protein constituent of VLDL and appears to be important for the hepatic uptake of triglyceride-rich lipoproteins. A new kindred of patients with type III hyperlipoproteinemia is described in which no plasma apolipoprotein E could be detected, consistent with the concept that type III hyperlipoproteinemia may be due to an absence or striking deficiency of apolipoprotein E.
Ghiselli et al. (1981) conducted a case report in Type III hyperlipoproteinemia. Apolipoprotein E deficiency was evaluated on Plasma apolipoprotein E levels. A new kindred of patients with type III hyperlipoproteinemia was found to have no detectable plasma apolipoprotein E, suggesting the condition may be due to an absence or striking deficiency of apo E.