Hypertension with left ventricular hypertrophy was associated with significantly lower left atrial reservoir, conduit, and booster pump functions, and greater left atrial stiffness than controls.
Observational (n=59)
Do hypertensive patients with left ventricular hypertrophy have impaired left atrial function compared to normotensive controls?
Hypertensive patients with left ventricular hypertrophy exhibit significant impairment in all components of left atrial function, which correlates with LV hypertrophy and diastolic dysfunction.
OBJECTIVE: The aim of this study was to comprehensively investigate left atrial (LA) reservoir, conduit, and booster pump functions, as well as their predictors in patients with primary systemic arterial hypertension (HTN) and left ventricular (LV) hypertrophy. METHODS: Thirty patients with HTN and LV hypertrophy, but no history of atrial arrhythmia or heart failure, were compared with 29 normotensive controls. Speckle-tracking echocardiography of the LA wall was used to measure systolic and diastolic strains and strain rates. Early diastolic velocity of transmitral flow/early diastolic mitral annular motion velocity (E/E')/peak systolic LA strain (S-LAs) was used as an index of LA stiffness. RESULTS: HTN patients had higher LV mass index, impaired LV diastolic function, and higher LA volume index than controls. LA reservoir, conduit, and booster pump functions were significantly lower and LA stiffness was greater. Multiple regression analysis indicated that increased LV mass and LV filling pressures as well as reduced LV strain or E' were predictors for reduced atrial function. CONCLUSION: HTN patients showed a significant impairment of the three components of LA function. These changes were correlated with LV hypertrophy and dysfunction, and presumably related to LA fibrotic changes, underlining the importance of LA-LV coupling. The prognostic value of these new speckle-tracking echocardiography-based LA strain indices needs to be evaluated by future studies.
Soullier et al. (Wed,) conducted a observational in Primary systemic arterial hypertension and left ventricular hypertrophy (n=59). Primary systemic arterial hypertension and left ventricular hypertrophy vs. Normotensive controls was evaluated on Left atrial (LA) reservoir, conduit, and booster pump functions, and LA stiffness. Hypertension with left ventricular hypertrophy was associated with significantly lower left atrial reservoir, conduit, and booster pump functions, and greater left atrial stiffness than controls.
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