Successful fetal cardiac intervention for aortic stenosis increased the rate of biventricular circulation at discharge compared to no or unsuccessful intervention (42.8% vs 19.4%).
Cohort (n=370)
Yes
Does fetal cardiac intervention improve survival to hospital discharge and biventricular circulation in fetuses with cardiac anomalies?
Fetal cardiac intervention for aortic stenosis/evolving HLHS may increase the likelihood of achieving biventricular circulation at hospital discharge.
Absolute Event Rate: 42.8% vs 19.4%
BACKGROUND: Invasive fetal cardiac intervention (FCI) has been reported in single-institution series, promoting technical and physiologic success. OBJECTIVES: This study describes the creation of an international registry of cases presenting for FCI, intended to compile technical and outcome data from a multicenter cohort. METHODS: For this initial analysis, the entire database of the International Fetal Cardiac Intervention Registry (IFCIR) was queried for details of diagnoses, procedures, and outcomes. Maternal-fetal dyads from January 2001 through June 2014 were included. RESULTS: Eighteen institutions submitted data by data harvest. Of 370 cases entered, 245 underwent FCI: 100 aortic valvuloplasties from a previous single-center report (excluded from additional reporting here), an additional 86 aortic and 16 pulmonary valvuloplasties, 37 atrial septal cases, and 6 unclassified cases. FCI did not appear to affect overall survival to hospital discharge. Among live-born infants with a fetal diagnosis of aortic stenosis/evolving hypoplastic left heart syndrome, more than twice as many were discharged with biventricular circulation after successful FCI versus those meeting institutional criteria but without any or successful FCI (42.8% vs. 19.4%, respectively). When fetal deaths were counted as treatment failures, the percentages were similar: biventricular circulation at discharge was 31.3% versus 18.5% for those discharged with univentricular palliation. Survival to discharge for live-born fetuses with atrial restriction was similar to that of those undergoing technically successful versus unsuccessful FCI (63.6% vs. 46.7%, respectively), although criteria for diagnosis were nonuniform. CONCLUSIONS: We describe the contents of the IFCIR and present post-natal data to suggest potential benefit to fetal therapy among pregnancies considered for possible intervention and support proposals for additional work.
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Moon‐Grady et al. (2015) conducted a cohort in Fetal cardiac anomalies (n=370). Fetal cardiac intervention vs. No or unsuccessful fetal cardiac intervention was evaluated on Biventricular circulation at discharge among live-born infants with aortic stenosis/evolving hypoplastic left heart syndrome. Successful fetal cardiac intervention for aortic stenosis increased the rate of biventricular circulation at discharge compared to no or unsuccessful intervention (42.8% vs 19.4%).