Key result
Successful fetal cardiac intervention is linked to a ~121% higher rate of biventricular circulation at discharge.
Why the study?
Invasive fetal cardiac intervention had been reported primarily in single-institution series, prompting the need to compile multicenter technical and outcome data.
Does fetal cardiac intervention improve survival to hospital discharge and biventricular circulation in fetuses with cardiac anomalies?
Cohort (n=370)
Yes
Does fetal cardiac intervention improve survival to hospital discharge and biventricular circulation in fetuses with cardiac anomalies?
Absolute Event Rate: 42.8% vs 19.4%
Fetal cardiac intervention for aortic stenosis/evolving HLHS may increase the likelihood of achieving biventricular circulation at hospital discharge.
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Captured external expert commentary on this paper, strongest first. Original sources are linked where available.
“"At 20 weeks, families have little time to process and fewer options. At 12 weeks, we can give families the space and support to understand their baby's condition and make the right decisions for their specific situation."”
Successful FCI was associated with higher biventricular discharge rates in this cohort; leaves open whether randomized trials will confirm benefit.
Moon‐Grady et al. (2015) conducted a cohort in Fetal cardiac anomalies (n=370). Fetal cardiac intervention vs. No or unsuccessful fetal cardiac intervention was evaluated on Biventricular circulation at discharge among live-born infants with aortic stenosis/evolving hypoplastic left heart syndrome. Successful fetal cardiac intervention for aortic stenosis increased the rate of biventricular circulation at discharge compared to no or unsuccessful intervention (42.8% vs 19.4%).
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