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June 10, 2026European Heart Journal313 citationsOpen Access

Cell type-specific expression of the putative SARS-CoV-2 receptor ACE2 in human hearts

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LNLuka NicinWAWesley AbplanalpHMHannah Mellentin

Key Points

  • The study aims to investigate the specific expression of ACE2, the receptor for SARS-CoV-2, in human heart tissues.
  • Analyzed heart tissue samples for ACE2 expression across different cell types.
  • Used immunohistochemistry to assess receptor localization.
  • Focused on understanding implications for COVID-19-related cardiac issues.
  • Found variable ACE2 expression levels in heart cell types.
  • Identified significant ACE2 expression in endothelial cells, suggesting a pathway for SARS-CoV-2 entry.
  • Results highlight a potential link between COVID-19 and cardiovascular complications.

Abstract

The coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 infections imposes a major threat for the world’s healthcare systems and is leading to thousands of deaths. Angiotensin-converting enzyme 2 (ACE2) has been identified as a potential receptor for SARS

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Cite This Study

Nicin et al. (2020) studied this question.

synapsesocial.com/papers/6a28d7eac9ff7f3491e44778https://doi.org/10.1093/eurheartj/ehaa311
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