What question did this study set out to answer?

The study aims to investigate the specific expression of ACE2, the receptor for SARS-CoV-2, in human heart tissues.

June 10, 2026Open Access

Cell type-specific expression of the putative SARS-CoV-2 receptor ACE2 in human hearts

LNLuka NicinIntensive Care Foundation WAWesley AbplanalpGoethe University Frankfurt HMHannah MellentinGoethe University Frankfurt

Key Points

The study aims to investigate the specific expression of ACE2, the receptor for SARS-CoV-2, in human heart tissues.
Analyzed heart tissue samples for ACE2 expression across different cell types.
Used immunohistochemistry to assess receptor localization.
Focused on understanding implications for COVID-19-related cardiac issues.
Found variable ACE2 expression levels in heart cell types.
Identified significant ACE2 expression in endothelial cells, suggesting a pathway for SARS-CoV-2 entry.
Results highlight a potential link between COVID-19 and cardiovascular complications.

Abstract

The coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 infections imposes a major threat for the world’s healthcare systems and is leading to thousands of deaths. Angiotensin-converting enzyme 2 (ACE2) has been identified as a potential receptor for SARS

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Cite This Study

Nicin et al. (Mon,) studied this question.

synapsesocial.com/papers/6a28d7eac9ff7f3491e44778 https://doi.org/https://doi.org/10.1093/eurheartj/ehaa311

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