Key result
Human coronaviruses utilize renin-angiotensin system proteases like ACE2 and APN for cellular entry, and the subsequent downmodulation of these receptors may contribute to viral pathogenesis.
Population
Human coronaviruses (HCoVs) including HCoV-NL63 and HCoV-HKU1
Design
Review
Authors
Loading...
Suggests RAS proteases as antiviral targets in coronavirus infections; leaves open clinical efficacy of such interventions.
This review highlights the critical role of the renin-angiotensin system proteases as host cell receptors for human coronavirus entry and pathogenesis.
Wevers et al. (2010) conducted a review in Human Coronavirus Infection. Human Coronaviruses was evaluated. Human coronaviruses utilize renin-angiotensin system proteases like ACE2 and APN for cellular entry, and the subsequent downmodulation of these receptors may contribute to viral pathogenesis.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: