Enantiodivergent Construction of Oxa -Quaternary Carbon Centers via Desymmetrization Based on Palladium/Chiral Norbornene Cooperative Catalysis

Key Points

• This research aims to understand the mechanism and factors influencing enantiodivergent reactions in oxa-quaternary carbon centers.
• Utilized palladium and chiral norbornene for cooperative catalysis
• Conducted experimental studies alongside DFT calculations
• Investigated reaction mechanisms and enantioselectivity inversion
• Identified specific conditions leading to enantiodivergence
• Elucidated the reaction mechanism underlying enantiodiscrimination
• Demonstrated the potential for enantioselectivity inversion in the desymmetrization process