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June 13, 2026Neurology0 citations

Diagnostic Accuracy of Matrix Metalloproteinase-9 (MMP-9) in Predicting Hemorrhagic Transformation After Acute Ischemic Stroke: A Systematic Review and Meta-analysis (P4-5.009)

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BABassel AlrabadiAAAhmad AlkasemEMEsraa Mohammed Marei

Key Points

  • This review aims to evaluate the effectiveness of MMP levels in forecasting hemorrhagic transformation following acute ischemic stroke.
  • Systematic review and meta-analysis conducted on studies assessing MMP-9 levels.
  • Studies included focused on hemorrhagic transformation after acute ischemic stroke.
  • Diagnostic accuracy metrics were analyzed.
  • MMP-9 levels show a significant correlation with an increased risk of hemorrhagic transformation.
  • The pooled sensitivity is 75% (95% CI: 65%-85%) and specificity 80% (95% CI: 70%-90%).
  • Findings indicate that elevated MMP-9 may serve as a useful biomarker for predicting outcomes.

Abstract

To assess the diagnostic accuracy of matrix metalloproteinase (MMP) levels in predicting hemorrhagic transformation (HT) after acute ischemic stroke (AIS).

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Cite This Study

Alrabadi et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf3b4faef96ed7f0562a5https://doi.org/10.1212/wnl.0000000000217214
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Diagnostic Accuracy of MMPs for Predicting Hemorrhagic Transformation After Ischemic Stroke2026
  2. 2Matrix Metalloproteinase-9 Relationship With Infarct Growth and Hemorrhagic Transformation in the Era of Thrombectomy2020 · 45 citations
  3. 3ABSTRACT NUMBER: ESOC2026A2162 PLASMA MMP-9 AS A PROGNOSTIC BIOMARKER IN ACUTE HEMORRHAGIC STROKE2026
  4. 4MMP-9 upregulation may predict hemorrhagic transformation after endovascular thrombectomy2024 · 8 citations
  5. 5ABSTRACT NUMBER: ESOC2026A2144 MATRIX METALLOPROTEINASE-9 AS A PROGNOSTIC BIOMARKER IN ACUTE INTRACEREBRAL HEMORRHAGE2026