Asymmetric α-amination of aldehydes at low catalytic loading: application to the synthesis of solriamfetol and nateglinide

Key Points

• This research aims to achieve an efficient asymmetric α-amination of aldehydes using minimal catalytic loading.
• Utilized a nonsilyl bicyclic secondary amine organocatalyst at 0.1 mol %
• Incorporated propanoic acid at 100 mol % for reaction stability
• Assessed catalyst stability toward various conditions.
• Successfully synthesized solriamfetol and nateglinide using the new method.
• Demonstrated high efficiency and stability of the organocatalyst under low loading conditions.