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Made up out of air: The highly enantioselective oxidation of 3,4-substituted meso-pyrrolidines to Δ1-pyrrolines is reported. The reaction is catalyzed by monoamine oxidase from Aspergillus niger (MAO-N D5) and utilizes molecular oxygen from air as the stoichiometric oxidant. The corresponding Δ1-pyrrolines serve as useful building blocks for the synthesis of L-proline analogues and α-amino nitriles of high enantiomeric purity.
Köhler et al. (Tue,) studied this question.