Compared to patients <65 years, those aged ≥85 years had a higher risk of in-hospital mortality (adjusted OR 1.95; 95% CI 1.72-2.22), with a steeper increase among cardiac arrest patients.
Observational (n=35,265)
Yes
Does older age increase in-hospital mortality in patients admitted to the CICU?
Patients aged ≥85 years in contemporary CICUs experience survival comparable to those aged 75-<85 years, except in the setting of cardiac arrest, supporting consideration of factors beyond chronological age in triage.
Odds Ratio: 1.95 (95% CI 1.72–2.22)
BACKGROUND: Contemporary data characterizing older adults admitted to cardiac intensive care units (CICUs) across diverse indications are limited. OBJECTIVES: The objective of the study was to describe the clinical characteristics, critical care therapies, and in-hospital outcomes of older patients admitted to the CICU compared with younger adults. METHODS: The Critical Care Cardiology Trials Network is a multicenter, international registry of CICUs. Between 2017 and 2024, participating centers contributed annual ≥2-month snapshots of consecutive medical CICU admissions. Admissions were categorized into 4 age groups: <65, 65-<75, 75-<85, and ≥85 years. Outcomes included CICU and in-hospital mortality and length of stay. Multivariable models adjusted for sex, illness severity (SOFA score), lactate, and kidney function. RESULTS: Among 35,265 admissions from 50 sites, 44%, 27%, 21%, and 9% were aged <65, 65-<75, 75-<85, and ≥85 years, respectively. Acute coronary syndrome was the most common admission diagnosis among all age groups. Patients aged ≥85 years had the lowest use of mechanical circulatory support (5.5%), which consisted exclusively of intra-aortic balloon pumps. Relative to patients <65 years, adjusted ORs of in-hospital mortality were 1.53 (1.40-1.67) for 65-<75 years, 1.83 (1.67-2.01) for 75-<85 years, and 1.95 (1.72-2.22) for ≥85 years. Among cardiac arrest patients the increase in mortality with age was steeper, reaching 3.09 (2.24-4.26) for patients ≥85 years. CONCLUSIONS: Patients ≥85 years in contemporary CICUs experience survival comparable to those aged 75-<85 years, except in the setting of cardiac arrest. These findings support consideration of factors beyond chronological age in CICU triage and treatment decisions.
Tarabanis et al. (Mon,) conducted a observational in Cardiac intensive care unit admission (n=35,265). Older age (≥85 years) vs. Age <65 years was evaluated on In-hospital mortality (OR 1.95, 95% CI 1.72-2.22). Compared to patients <65 years, those aged ≥85 years had a higher risk of in-hospital mortality (adjusted OR 1.95; 95% CI 1.72-2.22), with a steeper increase among cardiac arrest patients.