A systematic review of 47 studies identified 14 in silico, 26 in vitro, and 7 in vivo modeling platforms for congenital heart disease, revealing a paucity of models specifically targeting atrioventricular septal defect valves.
Systematic Review (n=47)
Current modeling platforms for AVSD valves are limited, highlighting the need for multidisciplinary approaches to develop high-fidelity models for improving repair strategies.
Abstract Given the high rate of re-intervention in patients with atrioventricular septal defects (AVSD), there is a continuing need to accurately model the complex valve anatomy and surgical repair strategies. This systematic review examined the current scientific landscape for modeling platforms designed to study abnormal congenital heart valves that are used or could be used for AVSD investigation. Of 1,050 sources screened, 47 were included (14 in silico; 26 in vitro; 7 in vivo). In silico models studying valve pathologies have advanced in recent years, but few targeted AVSD valves. In vitro platforms allow comparisons of repair techniques, but have yet to be applied for AVSD valve repair. In vivo studies could offer physiologically accurate platforms, but face challenges such as replicating AVSD pathologies. Multidisciplinary approaches to creating high-fidelity, reproducible, physiologically accurate AVSD valve models can transform the understanding of AVSD valve properties and repair strategies.
Wang et al. (Thu,) conducted a systematic review in Atrioventricular septal defects (n=47). Modeling platforms (in silico, in vitro, in vivo) was evaluated on Number and type of modeling platforms for congenital heart valves. A systematic review of 47 studies identified 14 in silico, 26 in vitro, and 7 in vivo modeling platforms for congenital heart disease, revealing a paucity of models specifically targeting atrioventricular septal defect valves.