During a 52-week weight maintenance phase, exercise alone or in combination with liraglutide significantly reduced carotid intima-media thickness by 7% and 6% respectively, whereas liraglutide alone did not.
RCT (n=130)
Double-blind
1:1:1:1 ratio
No
Does exercise and/or liraglutide improve carotid intima-media thickness and inflammatory/endothelial biomarkers in adults with obesity after diet-induced weight loss?
Regular physical activity, with or without liraglutide, reduces carotid intima-media thickness and systemic inflammation during weight loss maintenance in adults with obesity, whereas liraglutide alone does not.
Effect estimate: 7% reduction (Exercise group) (95% CI 2 to 12)
p-value: p=0.01
Abstract Obesity and inactivity are linked to endothelial dysfunction and atherosclerosis. In this secondary analysis of the S-LiTE trial (ClinicalTrials.gov identifier: NCT04122716 ; EudraCT identifier: 2015–005585-32 ), 130 adults with obesity completed a diet-induced weight loss plan, followed by randomization to weight maintenance with exercise and/or liraglutide for 52 weeks. We show that exercise, alone or in combination with liraglutide, reduces carotid intima-media thickness and systemic pro-inflammatory cytokine levels (interleukin-6 and interferon-γ). Combination treatment also improves endothelial function biomarkers (sICAM-1, sVCAM-1 and tPA). Liraglutide alone shows no such improvements. Overall, regular physical activity, with or without GLP-1R agonists, is essential for promoting vascular health in adults with obesity.
Sandsdal et al. (Wed,) conducted a rct in Obesity (n=130). Exercise and/or Liraglutide vs. Placebo with usual activity was evaluated on Change in carotid intima-media thickness (cIMT) (7% reduction (Exercise group), 95% CI 2 to 12, p=0.01). During a 52-week weight maintenance phase, exercise alone or in combination with liraglutide significantly reduced carotid intima-media thickness by 7% and 6% respectively, whereas liraglutide alone did not.